Hi {!firstname_fix}

Here is your newest copy of our new online newsletter. We are refining as we go. I am always interested in your input. Please feel free to pass it on to your friends and family.

Warmly,


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December 8, 2003
** Quote From Kathleen **

You cannot heal addiction in isolation


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** Testimonial for the Week**

When I started this program I was in a real panic. I had high blood pressure, which was uncontrollable even with medications, terrible mood swings/rages, a lifetime of depression, and edema so bad my legs were hard from my toes to my hips. I couldn't walk much and, since I was 57, I was terrified I'd have a stroke or heart attack before I got to step 7.

I had been promised success (which I never achieved) by so many diet gurus that I knew this program would not work. But others before me said it would, that I should have faith, that I needed to do the steps one at a time. I didn't believe it but I did it nonetheless because I had run out of options - I'd already tried every diet around and knew bypass surgery was usuccessful for most people.

It is two years since I started this program. I did each step in order, one at a time, because I was desperate. I listened to the voices I found on this list which said be sure I loved a step or made it a habit before I moved on. A step became a habit for me in about three weeks, so I moved to the next step once a month - not trusting my own judgment - I worked on each step an extra week

. I gained some weight and went into a panic. "They" said it was ok, it had happened to them, it would come back off. I questioned eating carbs and fat. "They" said it would be ok. I questioned whether it would work for me. "They" said it would.I questioned every single day for six months. I didn't trust it because I'd been fooled so many times. I was depressed and anxious and angry. But I did it.

I could have saved myself the agony. At Step 3 I started losing the extra weight and it was gone by Step 6 (plus more). My last blood tests were excellent: I moved from the doctor telling me I needed to go on chloesterol medications to the normal ranges in all categories. I don't get edema anymore and I can walk farther and better than I have in years. I don't get depressed and don't have mood swings. I am more honest with myself and others around me - I can admit to being human - and it's paying off because I'm finding I'm an ok person.

What's not to like about this program? Well, you have to do it. And you need to post every day - that's what works best with recovery programs. I was desperate enough that I stacked the deck in my favor as best I could and posted a lot every day. I still do! I'm worth the effort and it's paying off.

And in case you're wondering, I eat 42 grams of protein per meal. This morning I had Pablo's omelet for breakfast: 3 eggs, butter, 1/4 C. cheese, 1/2 can refried beans, lettuce, tomatoes, onion, avocado, salsa and sour cream. Yummy, filling, and very satisfying.

Good luck to you. Trust. Believe. Post!!

Carrie

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** Your Last Diet: More Than What You Think**

Your Last Diet! YOUR Last Diet! Your LAST Diet! Your Last DIET!


All of the above. But way more. I thought I was designing the be all, end all weight loss program, but we got something way more than that. The connection is amazing. We are literally learning the process together.

Many people have asked me, *Why would I bother joining YLD if I am not interested in weight loss?* Well, because we have so much fun and talk about such interesting things. I thought you would like to come see the index for the topics of the chats we've held this year through October. You will need Adobe Acrobat to read the PDF file.

Here it is for 2003 Chats.

Then come join us and get in on the action!


http://www.radiantrecovery.com/YLD_signup.htm


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** Featured Product **



We are going to start offering things for that sweet puppy of yours! Coolspot is one of those insider products I stumbled on. You spray it on hotspots or any kind of dermatitis. It has all sorts of unbelievable testimonials. I thought, *oh yah,yah*. Then I got it. Man, it is awesome. So I thought, well, all right, let's have it on hand for all of you as well. We are putting it on puppy sale this week.

Our special promotion of products to Support Your Program for the Holidays is continuing for another week. You all got so excited and begged me. LOL what can I do! Just click here to check it out

Radiant Recovery Store

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** Science Tip **

Insulin Affects Polycystic Ovary Syndrome
by Kathleen DesMaisons, Ph.D.


Insulin resistance is known to have an important role in the development of polycistic ovary syndrome. Insulin resistance can develop when we use more sugars and foods evoking as insulin response (such as white things). These things create a blood sugar reaction. Because we are sensitive to carbohydrates, our body over responds and releases more insulin than a normal body would.

Over time, the number of insulin receptors decrease (down regulation) and our bodies are less responsive to the effects of insulin. The sugar in the blood stays high because the insulin can't get the sugar into the cells. Then the body gets concerned. High sugar, better produce more insulin. This results in a state called hyperinsulinemia, or high insulin. This combination is known as insulin resistance.

Hyperinsulinemia is not a good state health wise. The PnP plan is specifically designed to reduce insulin levels and increase the sensitivity of the body to insulin's effects. This reduces insulin resistance and may account for the fact that we are hearing about so many women getting relief from their PCOS after doing the plan for a few months.

Dunaif A. Insulin action in the polycystic ovary syndrome. Endocrinol Metab. Clin. North Am. 1999 Jun;28(2):341-59

Ehrmann DA. Insulin-lowering therapeutic modalities for polycystic ovary syndrome. Endocrinol Metab. Clin. North Am. 1999 Jun;28(2):423-38, viii

You can read any of these articles by going to PubMed.
Do a search by author by putting in the last name and initial like this - Panksepp, J.

http://www.ncbi.nlm.nih.gov/PubMed/

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** Featured Topic**

Some Thoughts on Fats and Cancer
by Kathleen DesMaisons, Ph.D.

Background
I recently began reviewing the scientific literature for the relationship between fats and br.... cancer.[I am putting that word about female mammary glands in code so your Spaminator doesn't axe my newsletter. I hope you will forgive me. If you want a copy in full English, please click here.]

I had heard about the high fat/br.... cancer connection, but wanted to understand the issues more in depth. It is striking to me that more information has not been provided to the public on the role of fats in cancer treatment outcomes. This short paper will give you a summary of the material I have found.

“These results indicated that a high-fat diet rich in Omega-3 fatty acids can suppress human br.... cancer cell growth and metastasis.” (Rose) Strong words, but they sure seem to be warranted by the evidence in the literature. The use of the term suppress (my emphasis) is shown throughout the literature.

The fat/cancer connection

Thirty years ago, a strong correlation was made between high fat diets and the initiation and course of br.... cancer (Rao). Mice fed corn oil had tumors that grew 3-4 times larger than those in the mice fed fat free diets. This was found to be true even on diets of 20% fat levels (Ip). A 20% fat level would not now be considered “high” fat by the generally accepted standards. High fat is now thought of as greater than 30%. Tumor weight increased proportionately to the amount of corn oil fed.

In the mid-eighties, researchers started to differentiate the kinds of fats people were eating and began to demonstrate that it was not the overall amount of fat so much as the type of fats being eaten. The findings about corn oil inducing mammary tumors were replicated numerous times. Cold water fish oil was found to have an inhibitory effect on br.... cancer tumors (Braden).

The differentiation of the importance of the type of fat on br.... cancer growth was studied more and more. Br.... cancer researchers started to see that Omega-6 fatty acids (those found in corn oil and saturated fats) were strongly associated with the incidence, size and rate growth of tumors. Tumor growth was significantly inhibited in animals given Omega-3 fatty acids as fish oil (Kort). They also found that low levels of Omega-3 fatty acids (those found in fish and flax oils) were predictive of the incidence and severity of metastasis. (Bougoroux) Further studies showed that Omega-3 fatty acids delay or reduce tumor development, and create a statistically significant decrease in metastasis (Cave, Fay). Increased Omega-3 fatty acids prolong survival (Gogos), enhance the effectiveness of chemotherapy (Das), and reduce the negative impact of radiation treatment (Gramaglia).

Other studies were done showing the effect of Omega-3 fatty acids from flaxseed and flax oil on other types of cancer. These studies showed a reduction of epithelial cell proliferation of melanoma cells by 40-50% (Serraino), a reduction of tumor volume by 50% (Thompson), a reduction of metastasis by 50-64% (Yan). A positive anti-estrogenic effect from flax was found to be equivalent to half of that of Tamoxifan with no side effects (Ocheson). Researchers found a differential effect of flaxmeal and flax oil with the meal being more beneficial as a protectant in the promotional phase of cancer and the oil being more effective in the reduction of already established tumors (Thompson).

Clinical Implications

Based on these finding, I have some specific suggestions for clinical intervention:
  1. Strongly encourage people to stop using products high in Omega-6 fatty acids. The biggest culprit is corn oil. Stay away from products with corn oil. Do not use margarine. It is hydrogenated oil and will exacerbate the negative effect of Omega-6 fatty acids.

  2. If you will be encouraging people to use protein shakes as a nutritional intervention, steer them away from commercially prepared options. Most of these preparations use corn oil as the lipid and include high amounts of refined sugar. I have included a recommendation for an ideal shake mix that provides 20-25 grams of protein, excellent carbohydrate and a good source of Omega-3 fatty acids.

  3. Reduce saturated fats as much as possible. Be realistic on this one. I often encourage people to try to eat more fish rather than meat, use olive oil rather than butter and steer towards lower fat cheeses. You do NOT want to encourage a strict low fat diet because that can also reduce the amount of Omega-3 fatty acids. Work towards moderate fats with a high proportion of Omega-3 fats and neutral monounsaturated fats like olive oil, almonds and avocados. The Omega Diet by Artemis Simopoulos, M.D. is the best book I have found on the subject of fats.

  4. Encourage a significant increase in Omega-3 fats - found in fish and flax meal and oil. I encourage people to eat salmon frequently and if appropriate to take salmon capsules several times a day. I will be working with some experienced clinicians to identify ideal levels. For now, I am recommending between 6-18 grams of cold water fish (I recommend salmon) oil per day in 3 divided doses depending on the symptoms being addressed and the weight of the person. The capsules generally come as 1 grams units.
Some people, particularly those who are sugar sensitive and may have lower levels of functioning lipase activity, do not seem to tolerate the fish oil well. The addition of digestive enzymes including lipase prior to taking the capsules seems to eliminate the fish-taste regurgitation.

The addition of flax oil (or a combination oil such as Udo's mixture) to the regime may enhance the effect of the increased omega-3 fatty acids. They appear to have slightly differing effects and may be synergistic.

Because flax oil has anti-estrogenic properties, it is useful in treating symptoms such as hot flashes. It also appears to have a chemoprotective effect for post-menopausal women. However, by the same token, it is not advised for use with pregnant or lactation women because at higher doses flax may affect fetal reproductive development.

George's Shake®

1 1/2 cups of low fat milk, soymilk or oatmilk (I recommend oat milk because of its overall health value). Get the ones that do not have added sugars. The natural sugar found in milk or oatmilk does not present a problem. Do not use rice milk or almond milks because they seem to trigger cravings for “sweet.” Adjust the amount of liquid to get the taste and consistency you like.

1/2 c. juice. Choose whatever juice you find the most comforting. Some people forgo the juice and simply use more milk liquid.

2 TBS. Protein Powder (or enough to get 20- 25 grams of protein). Use one with no sugars. I like Naturade NRG the best because it is a mixed protein (whey, egg and soy) with a great taste. Naturade makes other options if you prefer all soy, or vegetable to all whey.

2 TBS oatmeal (use non-instant rolled oats). If you don't like the grittiness of them, put them in the blender first and pulverize them.

1-2 TBS flax oil or a mixed oil such as Udo's or 2 TBS flax meal (fresh ground - it goes rancid very quickly. Do not use whole flaxseeds because they are not digestible. Unless ground).

Fruit if you like. 1/2 a banana, a few frozen strawberries, some frozen blueberries.

This shake is an ideal meal for on-the-run or falling off the cliff. You should not use it more than once a day. It is fine for children to have.

Bibliography on Some Thoughts on Fats and Cancer
Bartsch H, Nair J, Owen RW. Dietary polyunsaturated fatty acids and cancers of the br.... and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis. 1999 Dec;20(12):2209-18. Review.

Bougnoux P, Koscielny S, Chajes V, Descamps P, Couet C, Calais G. alpha-Linolenic acid content of adipose br.... tissue: a host determinant of the risk of earlymetastasis in br.... cancer. Br J Cancer. 1994 Aug;70(2):330-4.

Bougnoux P, Koscielny S, Chajes V, Descamps P, Couet C, Calais G., Braden LM, Carroll KK. Dietary polyunsaturated fat in relation to mammary carcinogenesis in rats. Lipids. 1986 Apr;21(4):285-8.

Cave WT Jr. Dietary omega-3 polyunsaturated fats and br.... cancer. Nutrition. 1996 Jan;12(1 Suppl):S39-42. Review.

Cave WT Jr. Omega-3 polyunsaturated fatty acids in rodent models of br.... cancer. Br.... Cancer Res Treat. 1997 Nov-Dec;46(2-3):239-46. Review.

Connolly JM, Gilhooly EM, Rose DP. Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 br.... cancer cell growth and apoptosis in nude mice. Nutr Cancer. 1999;35(1):44-9.

Connolly JM, Liu XH, Rose DP. Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human br.... cancer cell growth and metastasis in nude mice. Nutr Cancer. 1997;29(1):48-54.

Das UN. Reversal of tumor cell drug resistance by essential fatty acids. Lipids. 1999;34 Suppl:S103.

Fay MP, Freedman LS. Meta-analyses of dietary fats and mammary neoplasms in rodent experiments. Br.... Cancer Res Treat. 1997 Nov-Dec;46(2-3):215-23.

Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Cancer. 1998 Jan 15;82(2):395-402.

Gramaglia A, Loi GF, Mongioj V, Baronzio GF. Increased survival in brain metastatic patients treated with stereotactic radiotherapy, omega three fatty acids and bioflavonoids. Anticancer Res. 1999 Nov-Dec;19(6C):5583-6.

Ip C, Carter CA, Ip MM. Requirement of essential fatty acid for mammary tumorigenesis in the rat. Cancer Res. 1985 May;45(5):1997-2001.

Kalamegham R, Carroll KK. Reversal of the promotional effect of high-fat diet on mammary tumorigenesis by subsequent lowering of dietary fat. Nutr Cancer. 1984;6(1):22-31.

Kort WJ, Weijma IM, Bijma AM, van Schalkwijk WP, Vergroesen AJ, Westbroek DL. Omega-3 fatty acids inhibiting the growth of a transplantable rat mammary adenocarcinoma. J Natl Cancer Inst. 1987 Sep;79(3):593-9.

Li D, Yee JA, Thompson LU, Yan L. Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. Lett. 1999 Jul 19;142(1):91

Orcheson LJ, Rickard SE, Seidl MM, Thompson LU. Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats. Cancer Lett. 1998 Mar 13;125(1-2):69-76.

Rao GA, Abraham S. Enhanced growth rate of transplanted mammary adenocarcinoma induced in C3H mice by dietary linoleate. J Natl Cancer Inst. 1976 Feb;56(2):431-2.

Rose DP, Connolly JM, Coleman M. Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human br.... cancer cell solid tumors growing in nude mice. Clin Cancer Res. 1996 Oct;2(10):1751-6.

Rose DP, Connolly JM. Influence of dietary linoleic acid on experimental human br.... cancer cell metastasis in athymic nude mice. Int J Oncol. 1998 Dec;13(6):1179-83.

Rose DP, Connolly JM. Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther. 1999 Sep;83(3):217-44. Review.

Senzaki H, Iwamoto S, Ogura E, Kiyozuka Y, Arita S, Kurebayashi J, Takada H, Hioki K, Tsubura A. Dietary effects of fatty acids on growth and metastasis of KPL-1 human br.... cancer cells in vivo and in vitro. Anticancer Res. 1998 May-Jun;18(3A):1621-7.

Serraino M, Thompson LU. The effect of flaxseed supplementation on early risk markers for mammary carcinogenesis. Cancer Lett. 1991 Nov;60(2):135-42.

Thompson LU, Rickard SE, Orcheson LJ, Seidl MM. Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis. Carcinogenesis. 1996 Jun;17(6):1373-6.

Thompson LU. Experimental studies on lignans and cancer. Baillieres Clin Endocrinol Metab. 1998 Dec;12(4):691-705. Review.

Tou JC, Chen J, Thompson LU. Flaxseed and its lignan precursor, secoisolariciresinol diglycoside, affect pregnancy outcome and reproductive development in rats. J Nutr. 1998 Nov;128(11):1861-8.

Yan L, Yee JA, Li D, McGuire MH, Thompson LU. Dietary flaxseed supplementation and experimental metastasis of melanoma cells in mice. Cancer Lett. 1998 Feb 27;124(2):181-6.